OUR TECHNOLOGY FOCUS AREAS

Ascendia specializes in the application of nano-technology approaches to overcome solubility hurdles and develop novel pharmaceutical products.  Nano-technology in the pharmaceutical field encompasses many types of formulation approaches, from nano-particles, to self-emulsifying lipid systems, to dispersed amorphous systems, to nano-emulsions.  Ascendia’s suite of state-of-the-art technologies for formulating poorly water soluble compounds provide sophisticated formulation options for our clients, and the unique dosage forms we create can be administered orally, topically, or by injection.

Developing long-acting oral medications for poorly soluble drugs is particularly challenging.  The formulation design has to take into account the transit time in the gastrointestinal tract, the pH of the stomach and intestine both with and without food, salinity and interaction with bile salts, and many other considerations.  Ascendia has expertise developing coated particles and molecularly dispersed systems that can overcome these challenges.  Our dosage forms solubilize the drug in small particles that when disseminated in the GI tract allow the drug to dissolve more readily.  The particles contain coatings that are time and pH sensitive so that a controlled release effect is achieved as the particles transit the GI tract.