FORMULATIONS FOR POORLY SOLUBLE AND LOW BIOAVAILABILITY DRUGS

Ascendia specializes in the development of market suitable formulations for poorly water soluble drug substances. Based on the pre-formulation data package and the delivery requirements for the product, we recommend a comprehensive formulation development strategy. We understand that each formulation is unique and must address the specific challenges associated with poor solubility, inadequate bioavailability, and/or unacceptable physical/chemical stability. We also understand the urgency companies have for progressing their pipeline, and our approach maximizes the probability of success by exploring multiple formulation options in parallel if necessary.

Our experienced formulation development team can overcome these issues. Our services will provide you with a formulation that you can be confident will be suitable for clinical scale-up. Ascendia provides these expert contract formulation development services rapidly and cost-effectively – let us help bring your molecule to market.

We develop and evaluate oral and parenteral formulations for preclinical and early human studies. In addition to traditional granulation approaches, we offer a wide range of advanced technologies for your drug delivery challenges.

• Our nano-emulsion formulations are prepared by high shear homogenization and then incorporated into either solid or liquid dosage forms suitable for either oral or injectable administration.
• Our amorphous solid dispersions can be processed by hot-melt extrusion, solvent evaporation, or spray drying, and then granulated and tableted for oral administration.
• Our nano-particle formulations are prepared by bead-milling, microfluidization, or homogenization, and then incorporated into a solid dosage form, or suspended for injection.
• Our controlled-release formulations can provide enteric protection, colon targeting, sustained release with pH-independence, pulsed release or combinations thereof. Dosage forms can be either a capsule or tablet.